Know your product modes of action
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November 18, 2025
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By Lisa Beirn, Ph.D., technical services manager for Syngenta
General Principles | Fungicides | Herbicides | Insecticides | Explore Modes of Action
Whether applying alone or tank mixing, it's essential to have knowledge of modes of action to help prolong product efficacy for fungicides, insecticides and herbicides. Modes of action, represented as Fungicide Resistance Action Committee (FRAC) codes, Insecticide Resistance Action Committee (IRAC) codes and Herbicide Resistance Action Committee (HRAC) codes, are typically listed on product labels.
Mixing products with different modes of action can help lessen the chance your application will lead to disease, insect or herbicide resistance:
Fungicides that target a specific site within a pathogen present a higher risk of developing resistance, while multi-site fungicides are classified as having a low-risk potential for resistance (e.g., Secure® Action™ fungicide, FRAC group 29). Learn more about diseases that are high risk for developing resistance in this Golf Course Management article. - Tank mixing:
- Ensures complete activity against target pathogens by using multiple active ingredients
- Improves disease control when multiple pathogens are present
- Pre-mixed combinations:
- Offer convenience of multiple active ingredients in one jug and less container waste (e.g., Posterity® XT fungicide combines ADEPIDYN® technology for dollar spot control and the strength of Headway® fungicide active ingredients for broad-spectrum disease control)
- Economical option for both common and difficult-to-control diseases
Insect resistance is less likely to occur for insects with annual life cycles, like white grubs, where genetic changes happen at a slower pace. - For example, one application of Acelepryn® insecticide (group 28) or Acelepryn Xtra insecticide (group 4 and 28) in spring is effective for season-long control of masked chafer white grubs, among other species.
- Insects that reproduce rapidly, have multiple generations per season and are repeatedly exposed to the same active ingredient are more likely to develop levels of resistance (e.g., southern chinch bugs, annual bluegrass weevil)
- Strategies for preserving control options:
- Use resistant turfgrass species or cultivars
- Reduce treatment frequency
- Rotate modes of action
- Apply control measures specific to target insect through correct identification, monitoring and action thresholds
Herbicide resistance management in turf is not just a tank mix of different modes of action. A weed control strategy should employ all possible herbicide options outlined below: - Tank mixing: Broadens weed control spectrum.
- Post-emergent control: Use products like Monument® 75WG herbicide (group 2), Tenacity® herbicide (group 27) or Manuscript® herbicide (group 1) for weeds that escape herbicide applications, depending on turf type
- Employ an integrated strategy:
- Herbicides may not always have the same mode of action or activity on the same weed
- Use all available herbicide options (pre- and post-emergent)
- Include non-selective and mechanical (hand removal) methods
Product selection and mode of action - Carefully read each product label.
- Products that belong to the same FRAC, IRAC or HRAC group, may not necessarily control the same diseases, insects or weeds.
The Syngenta brand portfolio offers fungicides, insecticides and herbicides with a variety of modes of action to help you prevent and manage resistance:
| Syngenta Fungicides |
| Group | 3 | Banner Maxx® II (propiconazole) |
| Group | 4 | Subdue Maxx® (mefenoxam) |
| Group | 7 | Posterity (pydiflumetofen/ADEPIDYN technology), Velista® (penthiopyrad) |
| Group | 11 | Heritage®, Heritage TL (azoxystrobin) |
| Group | 11 | P1 | Heritage Action (azoxystrobin, acibenzolar-s-methyl) |
| Group | 12 | Medallion® SC (fludioxonil) |
| Group | 29 | Secure® (fluazinam) |
| Group | P7 | Appear® II (potassium phosphite) |
| Group | M5 | Daconil Weatherstik®, Daconil Ultrex®, Daconil Zn® Flowable (chlorothalonil) |
| Group | M5 | P1 | Daconil® Action™ (chlorothalonil, acibenzolar-s-methyl) |
| Group | 3 | 7 | Ascernity® (benzovindiflupyr/SOLATENOL technology, difenconazole) |
| Group | 3 | 7 | 11 | Posterity XT, Posterity Forte (propiconazole, azoxystrobin, ADEPIDYN technology) |
| Group | 3 | 11 | Briskway® (difenconazole, azoxystrobin), Headway® (propiconazole, azoxystrobin) |
| Group | 3 | M5 | 12 | Instrata® (propiconazole, fludioxonil, chlorothalonil) |
| Group | M5 | 3 | Concert® II (propiconazole, chlorothalonil) |
| Group | 29 | P1 | Secure Action (fluazinam, acibenzolar-s-methyl) |
| Group | 7 | Trefinti® (cyclobutrifluram/TYMIRIUM® technology) |
Visit FRAC.info to view all fungicides and their corresponding classifications.
| Syngenta Insecticides |
| Group | 3 | Scimitar® GC (lambda-cyhalothrin) |
| Group | 4 | Meridian® 0.33G, Meridian 25 WG (thiamethoxam) |
| Group | 4 + 28 | Acelepryn Xtra (thiamethoxam+chlorantraniliprole) |
| Group | 22 | Advion® brand insecticides (indoxacarb) |
| Group | 22 | Provaunt® WDG (indoxacarb) |
| Group | 28 | Acelepryn (chlorantraniliprole), Ference® (cyantraniliprole) |
| Group | 30 | Atexzo®* (isocycloseram/PLINAZOLIN® technology) |
*Pending registration with the U.S. Environmental Protection Agency Visit IRAC-online.org to view all insecticides and their corresponding classifications.
| Syngenta Herbicides |
| Group | 1 | Fusilade® II Turf and Ornamental Herbicide (fluazifop-p-butyl) |
| Group | 1 | Manuscript (pinoxaden) |
| Group | 2 | Monument 75WG, Recognition® (trifloxysulfuron sodium) |
| Group | 3 | Barricade 4FL, Barricade 65WG (prodiamine) |
| Group | 15 | Pennant Magnum (S-metolachlor) |
| Group | 22 | Reward® (diquat dibromide) |
| Group | 27 | Tenacity (mesotrione) |
Visit HRACglobal.com to view all herbicides and their corresponding classifications.
| Syngenta Nematicides |
| Group | N-2 | Divanem® (abamectin) |
| Group | N-2 | Trefinti (cyclobutrifluram/TYMIRIUM technology) |
Visit IRAC-online.org to view all nematicides and their corresponding classifications.
Resistance management is an important consideration used in the development of Syngenta agronomic programs. These proven programs help turf become fit before the season, provide exceptional turf quality for players and recover from stress like insects, disease, heat, drought, aerification and traffic. To find an agronomic program that can assist in managing resistance for your area, visit ConditionPerformRecover.com.
© 2025 Syngenta. Important: Always read and follow label instructions. Some products may not be registered for sale or use in all states or counties and/or may have state-specific use requirements. Please check with your local extension service to ensure registration and proper use. Atexzo and PLINAZOLIN are not yet registered for sale or use in the United States and are not being offered for sale. Divanem and Scimitar GC are Restricted Use Pesticides. The trademarks or service marks displayed or otherwise used herein are the property of a Syngenta Group Company. Secure® is a registered trademark of Ishihara Sangyo Kaisha, LTD. All other trademarks are the property of their respective third-party owners.